SOP For Cleaning Procedure of Production Area

Learn how to write a standard cleaning procedure of production area in pharmaceutical industry.

1. PURPOSE

 To describe a proper house-keeping & cleanliness at the production areas for minimizing contamination.

2. SCOPE

 This procedure is applicable for cleaning of all production areas in this pharmaceutical.

3. ASSOCIATED DOCUMENTS

Nil

4. PRECAUTIONS

4.1 Wear apron and mask appropriately before starting of cleaning.

4.2 Always use freshly prepared detergent and disinfectant solution.

4.3 Check the purified water supply before starting of cleaning.

5. RESPONSIBILITIES

5.1 Operator, helper and cleaners are responsible for cleaning of production are

5.2 Production Executive is responsible for checking and ensuring the cleaning of all areas in the Production Department.

5.3 Production Manager is responsible for implementation and cross checking and ensuring thecleaning of all areas in the Production Department.

6. ACCOUNTABILITY

Head of the Quality Assurance Department

7. PROCEDURE 

7.1 Clip a clean duster with a mopping stick.

7.2 Soak mopping edge with disinfectant solution.

7.3 Mop floor from furthest comer to opening side.

7.4 Clean specific areas at specific times of period according to the chart below:

Areas/ Objects	Mode  of  cleaning	Frequency
Floor (Machine Room)	By vacuum Cleaner, Wet mop	At each Product changeover / When required
Walls (Machine Room)	By dry & wet Cloth	At each Product changeover / When required
Doors and Windows (Machine Room)	By wet cloth	At each Product changeover / When required
Ceiling & Light sheds (Machine Room)	By wet cloth	At each Product changeover / When required
Floors (Dispensed material staging room, WIP store)	By vacuum cleaner and wet mop.	Twice per day
Floors  (All change room, corridors & stair, Tools room, IPQC room, Office room, Secondary Packaging area)	By vacuum cleaner, By wet cloth & 1% disinfectant	Twice per day/When required
Floor (Washing bay)	By wet mop & 1% disinfectant	Three times  per day/ When required
Walls (All Change rooms, Tools room, IPQC room, Office room, Secondary packaging area, Corridor, Dispensed RM staging room, WIP store & Washing bay)	By dry cloth duster	Once per week
Ceilings & Light sheds (All Change rooms, Secondary packaging area, Corridor, WIP store, Tools room, Dispensed RM staging room, IPQC room, Washing bay, Office room)	By dry cloth duster	Once per week
Racks (WIP store & Tools Room)	By wet cloth	Twice per week
Doors & Windows including glass (All Change rooms, Stair room, Secondary packaging area, corridor, WIP store, Tools room, Dispensed RM staging room, IPQC room, Washing bay, Office room)	By wet cloth duster  and glass cleaner	Once per day
Table, Chair, Working bench, dress locker & step over bench	By wet / dry cloth duster	Once per day
Waste bins	By cleaning agent	At each Product changeover / Once daily / When required
Return air duct filter	By purified water & compressed air	At each Product changeover
Trolleys	By wet cloth	After each use / When required

7.5 Use of disinfectant solution: 1^st week- Savlon, 2^nd week – Dettol, 3^rd week Savlon, 4^th week-   Dettol and so on.

7.6 Keep the record in the Room Cleaning Log Book & Production Area Cleaning Log Book and fill up the Cleaning Check Sheet,

where necessary.

Read Also: SOP for Cleaning of Sampling Tools

SOP for Cleaning of QC Laboratory

8. ABBREVIATIONS

8.1 SOP: Standard Operating Procedure          

8.2 PRO: Production

9. APPENDICES

9.1 Annexure-1: Room Cleaning Log Book Register.               

9.2 Annexure-2: Production Area Cleaning Log Book Register

SOP For Cleaning Procedure of Production Area Annexure-1: Room Cleaning Log Book Register.   

SOP For Cleaning Procedure of Production Area Annexure-2: Production Area Cleaning Log Book Register. 

ANNEXURE-2 Production Area Cleaning Log-book Register

Date	Start Time	End Time	Daily	Twice per week	Once per week	Cleaned by	Checked by	Remarks
			Doors, Floor, Chair, Bench, Table	Racks	Ceilings, Light sheds, Wall